Treatment Regimen for H.Pylori Eradication

 

1. Triple Therapy (14-day regimen)

 Drugs:

  • Proton Pump Inhibitor (PPI) (e.g., Omeprazole) – twice daily
  • Clarithromycin – 500 mg twice daily
  • Amoxicillin – 1 g twice daily
    (or Metronidazole 500 mg twice daily if penicillin allergy)

Duration: 14 days (sometimes 10 days in practice)

Note: PPI helps in ulcer healing and increases antibiotic efficacy by raising gastric pH.

2. Bismuth-Based Quadruple Therapy (14-day regimen)

Drugs:

  • Proton Pump Inhibitor (PPI) – twice daily
  • Bismuth subsalicylate/subcitrate – 120 mg four times daily
  • Tetracycline – 500 mg four times daily
  • Metronidazole – 500 mg three to four times daily

Duration: 14 days

Note: Used in clarithromycin-resistant cases or after triple therapy failure.

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