List of All SOPs and Documents for In-vivo Laboratory

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Inflammation: 

1. Evaluation of Anti-Inflammatory Potential of Test Sample in Complete Freund’s Adjuvant Induced Inflammation in Experimental Animals (Chronic Model)

2. Evaluation of Anti-Inflammatory Potential of Test Sample in Carrageenan Induced Rat Paw Edema (Acute Model)

3. Evaluation of Anti-Inflammatory Potential of Test Sample in Cotton Pallet Granuloma Induced Inflammation in Experimental Animals

4. EVALUATION OF TEST SAMPLE FOR INFLAMMATORY PAIN USING CARRAGEENAN-INDUCED INFLAMMATORY PAIN IN EXPERIMENTAL ANIMALS

Arthritis:

1. Evaluation of Anti-Arthritic Potential of Test Sample Using Collagen Antibody-Induced Arthritis in Experimental Mice

2. EVALUATION OF ANTI-ARTHRITIC POTENTIAL OF PLANT EXTRACT(S) USING COLLAGEN-INDUCED ARTHRITIS (CIA) IN EXPERIMENTAL MICE

Toxicology:

1. Check Out the Tricks and Tips with Some Trouble Points While Conducting in OECD 407 and 408

2. EFFECT OF HERBAL FORMULATION EXTRACT ON ADRIAMYCIN-INDUCED CARDIOTOXICITY AND NEPHROTOXICITY IN RATS

3. TOXICOLOGICAL EVALUATION OF NATURAL PROBIOTIC FORMULATION USING EXPERIMENTAL ANIMALS

4. List of OECD Guidelines or Toxicological Studies

5. List of Guidelines for Toxicology Animal Studies

6. TWENTY EIGHT-DAYS REPEATED DOSE ORAL TOXICITY STUDY OF TEST FORMULATIONS IN RATS

Osteoarthritis:

1. Evaluation of Osteoarthritic Activity of Plant Extract(S)/ Herbal Formulation in New Zealand White Rabbits

2. Evaluation of Osteoarthritic Activity of Test Compound in Experimental Rats

Diabetes:

1. List of Study Plans for Various Models of Diabetes in Experimental Animals

Neuronal Disorders:

1. EVALUATION OF NEUROPROTECTIVE POTENTIAL OF TEST FORMULATIONS IN EXPERIMENTAL ANIMALS

2. EVALUATION OF TEST FORMULATIONS FOR PARKINSON’S DISEASE USING ROTENONE-INDUCED ANIMAL MODEL

3. EVALUATION OF TEST FORMULATION IN PREPARATION AND STANDARDIZATION FOR NOOTROPIC ACTIVITY

4. SOP FOR MOTOR COORDINATION TEST USING BEAM WALKING IN MICE

Immunomodulatory: 

1. EVALUATION OF IMMUNOMODULATORY POTENTIAL OF PLANT EXTRACT IN EXPERIMENTAL ANIMALS

2. EVALUATION OF IMMUNOMODULATORY POTENTIAL OF PLANT EXTRACT(S) IN EXPERIMENTAL ANIMALS

Liver Disorders:

1. EVALUATION OF HEPATOPROTECTIVE OF TEST FORMULATION AGAINST ANTI-TUBERCULAR  DRUGS-INDUCED  HEPATOTOXICITY

2. EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF HERBAL FORMULATION(S) USING ALCOHOL-INDUCED HEPATOTOXICITY IN EXPERIMENTAL ANIMALS

3. EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF TEST FORMULATION IN CCL4 –INDUCED HEPATIC DAMAGE IN RATS

4. EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF HERBAL FORMULATION(S) USING ANTI-TUBERCULOSIS DRUGS INDUCED HEPATOTOXICITY IN EXPERIMENTAL ANIMALS

Polycystic Ovary Syndrome:

1. Letrozole-induced Polycystic Ovary Syndrome Animal Model Study Points

Mucosal Damage:

1. MUCOPROTECTIVE ACTIVITY OF SHARK SQUALENE FOR ETHANOL-INDUCED MUCOSAL DAMAGE IN RATS

Intestinal Disorders:

1. EFFECT OF HERBAL EXTRACT ON EXPERIMENTAL MODELS OF INFLAMMATORY BOWEL DISEASES

2. STUDY PROTOCOL: EVALUATION OF NATURAL PROBIOTIC FORMULATION AGAINST ICE-COLD-INDUCED CONSTIPATION IN MICE.

3. Important points for TNBS Induced Colitis Model in Mouse

4. EVALUATION OF TEST FORMULATION FOR ANTI-COLITIS ACTIVITY USING DEXTRAN SULFATE SODIUM-INDUCED COLITIS IN EXPERIMENTAL ANIMALS.

5. EVALUATION OF TEST FORMULATION FOR ANTI-COLITIS ACTIVITY USING 2,4,6- TRINITROBENZENE SULFONIC ACID-INDUCED COLITIS IN EXPERIMENTAL ANIMAL

Ulcers: 

1. EVALUATION OF ANTI-ULCER ACTIVITY OF NATURAL PROBIOTIC FORMULATION USING EXPERIMENTAL ANIMALS

2. EVALUATION OF TEST FORMULATION FOR ANTI-ULCERATIVE ACTIVITY USING PYLORUS LIGATION-INDUCED ULCER IN EXPERIMENTAL RAT

3. EVALUATION OF TEST FORMULATION FOR ANTI-ULCERATIVE ACTIVITY USING INDOMETHACIN-INDUCED ULCER IN EXPERIMENTAL RAT

4. STUDY PROTOCOL: EVALUATION OF ANTI-ULCER ACTIVITY OF NATURAL PROBIOTIC FORMULATION USING EXPERIMENTAL ANIMALS

5. EVALUATION OF TEST FORMULATION FOR ANTI-ULCERATIVE ACTIVITY USING ALCOHOL-INDUCED ULCER IN EXPERIMENTAL RAT

6. EVALUATION OF TEST FORMULATION FOR ANTI-ULCERATIVE ACTIVITY USING STRESS-INDUCED ULCER IN EXPERIMENTAL RAT

Wound Healing:

1. What are the points that need to be considered before starting a diabetic wound healing study on rabbits? | Standardization of Diabetes Model in Rabbits

2. EVALUATION OF CURATIVE EFFECT OF PLANT EXTRACT(S)/HERBAL FORMULATION(S) ON INFECTED CHRONIC WOUNDS

CNS Disorders

1. Unpredictable Stress-Induced Depression Study in Animal Model

2. EVALUATION OF THE EFFICACY OF HERBAL FORMULATIONS IN RAT MODEL OF PHENCYCLIDINE (PCP)-INDUCED SCHIZOPHRENIA

3. EVALUATION OF ACTIVITY OF HERBAL FORMULATIONS IN RAT MODEL OF QUINPIROLE-INDUCED COMPULSIVE CHECKING BEHAVIOUR

Anemia:

1. Standardization of Anemia Model in Animals | Necessary Considerable Points before Anemia Study Initiation

2. EVALUATION OF HERBAL FORMULATIONS ON PHENYLHYDRAZINE-INDUCED ANAEMIA IN RATS

Psoriasis:

1. EVALUATION OF ANTI-PSORIASIS ACTIVITY OF HERBAL FORMULATION(S) USING IMIQUOMID-INDUCED (IMQ) PSORIASIS IN EXPERIMENTAL ANIMALS

2. EVALUATION OF ANTI-PSORIASIS ACTIVITY OF TEST FORMULATION(S) USING 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) PSORIASIS IN EXPERIMENTAL ANIMALS

3. Important highlighted points for psoriasis animal studies

4. SOP FOR 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLINE-5-ONE INDUCED PSORIASIS IN MICE

Kidney Injury:

1. Vancomycin (VCM) induced Acute Kidney Injury study protocols and important considerations

2. EVALUATION OF ANTUROLITHIASIS POTENTIAL OF PLANT EXTRACT(S) IN ETHYLENE GLYCOL-INDUCED UROLITHIASIS WISTAR RATS

Hypertension:

1. EVALUATION OF ANTI-HYPERTENSIVE ACTIVITY OF TEST FORMULATIONS IN RAT MODEL OF ONE KIDNEY ONE CLIP (1K1C) HYPERTENSION

Lung Disorders:

1. Cigarette Smoke and COPD: Important tips and procedures for BSE & Poly (I: C) induced lung inflammation

2. Asthma and Study protocol of House dust mite (HDM) induced chronic allergic asthma in mice

Dermatitis:

1. EVALUATION OF PROTECTIVE EFFECT OF TEST SAMPLE AGAINST 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE INDUCED ATOPIC DERMATITIS IN MICE

Pain & Analgesia:

1. EVALUATION OF PROTECTIVE EFFECT OF TEST SAMPLE IN SURGICALLY INDUCED NEUROPATHY PAIN USING CHRONIC CONSTRICTIVE INJURY (CCI) MODEL IN EXPERIMENTAL RAT

2. EVALUATION OF PROTECTIVE EFFECT OF TEST SAMPLE IN PACLITAXEL-INDUCED NEUROPATHY PAIN MODEL IN EXPERIMENTAL RAT

3. EVALUATION OF PROTECTIVE EFFECT OF TEST SAMPLE STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHY PAIN MODEL IN EXPERIMENTAL RAT

4. EVALUATION OF ANALGESIC POTENTIAL OF TEST COMPOUND(S) USING ACETIC ACID-INDUCED WRITHING TEST IN EXPERIMENTAL ANIMALS

5. EVALUATION OF ANALGESIC POTENTIAL OF TEST COMPOUND(S) USING FORMALIN TEST IN EXPERIMENTAL ANIMALS

6. EVALUATION OF ANALGESIC POTENTIAL OF TEST COMPOUND(S) USING HOT PLATE TEST IN EXPERIMENTAL ANIMALS

7. EVALUATION OF ANALGESIC POTENTIAL OF TEST COMPOUND(S) USING TAIL-FLICK TEST IN EXPERIMENTAL ANIMALS

8. EVALUATION OF TEST SAMPLE FOR INFLAMMATORY PAIN USING CARRAGEENAN-INDUCED INFLAMMATORY PAIN IN EXPERIMENTAL ANIMALS

Cancer:

1. EVALUATION OF ANTI-CANCER POTENTIAL OF PLANT EXTRACT(S)/HERBAL FORMULATION(S) USING HUMAN CANCER CELL LINE XENOGRAFT MODEL IN IMMUNOCOMPROMISED ANIMALS

2. EVALUATION OF ANTI-CANCER POTENTIAL OF PLANT EXTRACT(S)/HERBAL FORMULATION(S) USING HUMAN CANCER CELL LINE ORTHOTOPIC MODEL IN IMMUNOCOMPROMISED ANIMALS

3. INVESTIGATION OF ANTI-CANCER POTENTIAL OF PLANT EXTRACT USING MURINE CANCER CELL LINE XENOGRAFT MODEL IN EXPERIMENTAL ANIMALS

4. SOP FOR HUMANE INTERVENTION POINTS FOR RODENT CANCER MODELS

Glaucoma:

1. ASSESSMENT OF ANTI-GLAUCOMA POTENTIAL OF HERBAL FORMULATION IN NEW ZEALAND WHITE RABBITS

Parkinsonism:

1. EVALUATION OF EFFICACY OF TEST FORMULATIONS IN MOUSE MODEL OF MPTP AND PROBENECID-INDUCED PARKINSON’S DISEASE

Obesity:

1. Evaluation of Anti-Obesity Activity of Test Formulation Using High Fat Diet-induced Obesity in Experimental Animal 

In-vivo General SOPs:

1. STANDARD OPERATING PROCEDURE FOR ANESTHESIA

2. STANDARD OPERATING PROCEDURE FOR ANIMAL HANDLING DURING DOSE ADMINISTRATION

3. STANDARD OPERATING PROCEDURE  FOR  CONDUCTING BIOASSAY OF TEST ITEM FOR HUMAN CHORIONIC GONADOTROPHIN (HCG) ACTIVITY IN EXPERIMENTAL RATS

4. SOP FOR ELECTRONIC VON FREY 

5. SOP FOR -40 DEEP FREEZER

6. STANDARD OPERATING PROCEDURE FOR GROSS NECROPSY AND COLLECTION, WEIGHING & FIXATION OF ORGANS/TISSUES IN LABORATORY ANIMALS

7. STANDARD OPERATING PROCEDURE FOR OPERATION, MAINTENANCE OF TAIL FLICK UNIT

8. STANDARD OPERATING PROCEDURE THE PROCEDURE FOR OPERATION, MAINTENANCE, AND CALIBRATION OF PRESSURE APPLICATION MEASUREMENT

9. STANDARD OPERATING PROCEDURE FOR OPERATION AND MAINTENANCE OF THE PLETHYSMOMETER

10. STANDARD OPERATING PROCEDURE FOR OPERATION AND MAINTENANCE OF MORRIS WATER MAZE

11. STANDARD OPERATING PROCEDURE FOR OPERATION, AND MAINTENANCE OF ELEVATED PLUS MAZE.

12. STANDARD OPERATING PROCEDURE FOR OPERATION AND MAINTENANCE OF ROTAROD

13. STANDARD OPERATING PROCEDURE FOR THE OPERATION AND MAINTENANCE OF THE DIGITAL RANDALL SELITTO

14. STANDARD OPERATING PROCEDURE FOR OPERATION AND MAINTENANCE OF A STEREOTAXIC INJECTOR

15. SOP FOR OPERATION, MAINTENANCE, AND CALIBRATION OF VET AUTO HEMATOLOGY ANALYZER

16. SMALL ANIMAL NIBP SYSTEMS: SOP FOR OPERATION, SOFTWARE, AND TROUBLESHOOTING

17. STANDARD OPERATING PROCEDURE COLLECTION OF SERUM FROM WHOLE BLOOD

18. EVALUATION OF EFFICACY OF TEST FORMULATIONS IN RAT MODEL OF CROTON-OIL-INDUCED HEMORRHOIDS

19. EVALUATION OF THE EFFICACY OF TEST FORMULATIONS IN MOUSE MODEL OF MONOBENZONE-INDUCED VITILIGO   

Food Supplements:

1. EFFECT OF TWO FORMULATIONS (CONTAINING CALCIUM, PHOSPHORUS VITAMIN-D, AND  VITAMIN-B12 IN COMBINATION) ON THE SERUM LEVELS AFTER 28 DAYS OF TREATMENT IN RATS.

2. What is the amount of iron, vitamin D, B12 in iron, vitamin D, and B12 deficient diet prepared for rat experiments?

Others:

1. EVALUATION OF TEST FORMULATION ON THE PLATELET COUNTS IN CYCLOPHOSPHAMIDE-INDUCED THROMBOCYTOPENIC MODEL IN EXPERIMENTAL ANIMALS

2. EVALUATION OF THE EFFICACY OF HERBAL FORMULATIONS IN RAT MODEL OF CYCLOPHOSPHAMIDE-INDUCED THROMBOCYTOPENIA

3. Study Points in Male Pattern Baldness Model for Pre-clinical Studies 

4. EVALUATION OF EFFICACY OF TEST FORMULATION(S) IN RAT MODEL OF Α-NAPHTHYL-ISOTHIOCYANATE (ANIT)-INDUCED CHOLESTASIS

5. STANDARD OPERATING PROCEDURE FOR DESIGN OF AN ANIMAL STUDY PROTOCOL IN PRE-CLINICAL STUDY 

6. EVALUATION OF THE EFFICACY OF TEST FORMULATIONS IN MOUSE MODEL OF D-GALACTOSE-INDUCED ACCELERATED SENESCENCE-ASSOCIATED LEARNING AND MEMORY IMPAIRMENT 

7. SOP for the use of Streptozotocin in Rodents

8. EVALUATION OF THE EFFICACY OF TWO DIFFERENT TEST SAMPLES IN MOUSE MODEL OF MOG (MOG35-55) INDUCED EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (EAE).

9. ASSESSMENT OF ANTI-EPILEPTIC EFFICACY OF HERBAL FORMULATIONS IN A RAT MODEL OF KANIC ACID-INDUCED EPILEPSY

10. EVALUATION OF THE SLEEP-PROMOTING ACTIVITY OF HERBAL FORMULATIONS IN MOUSE MODEL OF CAFFEINE-INDUCED DISRUPTION OF BARBITURATE-INDUCED SLEEP

11. EVALUATION OF SPERMATOGENIC EFFECT OF HERBAL FORMULATION IN EXPERIMENTAL ANIMALS

12. EVALUATION OF EFFICACY OF TEST FORMULATIONS IN RAT MODEL OF L-ARGININE-INDUCED ACUTE PANCREATITIS

Surgical Procedures:-

1. List of material required for Carotory Artery Cannulation:- 

2. STANDARD OPERATING PROCEDURE FOR RODENT SURGERY

3. STANDARD OPERATING PROCEDURE (SOP) FOR RODENT OVARIECTOMY

4. STANDARD OPERATING PROCEDURE (SOP) FOR RODENT STEREOTAXIC SURGERY

 % Body Weight Change Excel

% BODY WEIGHT CHANGE 88kb

https://drive.google.com/file/d/17ZWre5jiEHdNTffYTE6kXWFCQxAme8qJ/view?usp=share_link

                                                             END OF DOCUMENTS

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