SOP FOR PROCUREMENT AND HANDLING OF LABORATORY CHEMICALS | STANDARD OPERATING PROCEDURE FOR PROCUREMENT AND HANDLING OF LABORATORY CHEMICALS

                   1.0                            OBJECTIVE

1.1                            To lay down a standard procedure to be followed for the procurement and handling of Laboratory chemicals in the Animal House Facility.

2.0                            SCOPE

2.1                            This Standard Operating Procedure (SOP) shall be applicable for the procurement and handling of Laboratory chemicals in the Animal House Facility.

3.0                            RESPONSIBILITY

3.1                            Head- Animal House Facility

3.2                            Attendant- Animal House Facility

4.0                            DEFINITIONS

4.1                            Nil

5.0                            PROCEDURE

5.1                            General instructions

5.1.1                      All chemicals shall be procured from the approved vendors.

5.1.2                      All solid and liquid chemicals shall be assigned use before date on receipt as indicated for solid chemicals & liquid chemicals as mentioned below.

5.1.2.1                Solid chemicals

5.1.2.1.1          Unopened condition: 5 years from the date of receipt or manufacturer’s expiry date whichever is earlier.

5.1.3                      Opened condition: 3 years from the date of opening.

5.1.3.1                Liquid Chemicals

5.1.3.1.1          Unopened condition: 3 years from the date of receipt or manufacturer’s expiry date whichever is earlier.

5.1.3.1.2          Opened condition: 1 year from the date of opening.

5.1.3.2                Bio-chemicals Kit

5.1.3.2.1          All the kits for Bio-Chemical, Enzymatic, and ELISA the based kit should be used as per the instruction of the Manufacturer.

5.1.3.2.2          Don't use an expired kit.

5.1.3.2.3          The manufacturer expiry date shall be followed if it is clearly stated on the label or certificate.

5.1.3.2.4          All chemicals shall be of AR, GR grade, LR grade, or ACS grade. A better grade can be procured depending on the requirement.

5.2                           Organization of Chemicals

5.2.1                      Procurement of the Chemicals

5.2.1.1                Chemicals shall be indented on the basis of the requirement, stock availability, and consumption.

5.2.1.2                To know the chemical availability, respective the chemical stock card shall be verified before raising any indent.

5.2.1.3                Stock cards shall be maintained for all chemicals in the laboratory as per Format no. F…………..

5.2.1.4                Minimum stock shall be maintained on the basis of procurement time.

5.2.1.5                Receiving the Chemicals

5.2.1.6                Upon receipt label the chemicals as per the details mentioned in Format no. F…………………..

5.2.1.7                Storage of Chemicals

5.2.1.8                All chemicals shall be stored as per the manufacturer’s instructions. The chemicals indicated to store at room temperature shall be stored in the reagent racks.

5.2.1.9                The chemicals / Bio Chemicals indicated to store at 2 to 8°C shall be stored in the refrigerator.

5.2.1.10            The chemicals indicated to store below 0°C shall be stored in the freezer.

5.2.1.11            Any other temperature if indicated, those chemicals shall be stored at a temperature lower nearest to the temperature indicated above.

5.2.1.12            The Bio Chemicals (for Enzymatic Parameter) will be stored as per instruction from the vendor.

5.3                            Handling

5.3.3 Care must be taken during the handling of all chemicals. Before using a chemical see the label on the bottle for the Hazard symbol. The following table consists of the Hazard symbols with the precautions to be taken during use.

                   

Sr.No.	Hazard	Symbol	Description of hazard	Caution
1.	Oxidizing	O	Oxidizing substances can ignite combustible material or worsen existing fires and thus make firefighting more difficult.	Keep away from combustible material
2.	Extremely flammable	F+	Liquids with flash points below 0°C and a boiling point/initial boiling point of max.35°C	Avoid contact with all sources of ignition
3.	Very toxic Toxic	T+ T	These substances are very hazardous to health when breathed, swallowed, or in contact with the skin and may even lead to death.  Non-recurring, recurring or lengthy exposure to these substances may result in irreversible damage	Avoid contact with the human body and immediately consult a doctor in case of malaise.
4.	Harmful	Xn	Inhalation and ingestion or skin penetration by these substances is harmful to health. Non-recurring, recurring or lengthy exposure to these substances may result in reversible damage.	Avoid contact with the human body, including inhalation of the vapors and in case of malaise consult a doctor.
5.	Highly flammable	F	Spontaneously flammable substances. Chemicals igniting in the air. Gases, and gas mixtures (also liquid ones) that have an ignition range with air at normal pressure. Substances are sensitive to moisture. Chemicals, readily form flammable gases in contact with water. Liquids with a flashpoint below 21°C. Solid substances ignite easily after a short-term effect of a source of ignition.	Avoid contact with air. Avoid the formation of flammable gas-air-mixtures and keep away from sources of ignition Avoid contact with moisture or water. Keep away from open fires, sources of heat, and sparks. Avoid contact with all sources of ignition.
6.	Corrosive	C	Living tissues, as well as equipment, may destroy contact with these chemicals.	Do not breathe vapors and avoid contact with skin, eyes, and clothing.
7.	Irritant	Xi	This symbol designates substances, which may have an irritant effect on the skin, eyes, and respiratory organs.	Do not breathe vapors and avoid contact with skin and eyes.
8.	Explosive	E	This symbol designates substances, which may explode under definite conditions.	Avoid shock, friction, sparks, and heat.

     

             

Sr. No.	Format Title	Format No.	No. of pages
1	Stock card for Chemicals / Bio-chemical kits	F…………….	01
2	Specimen Label for Reagent/Buffer	F…………….	01
3	Specimen Label for Chemical/Biochemical	F…………….	01

6.0 ABBREVIATIONS

6.1 SOP : Standard Operating Procedure

6.2 QAD : Quality Assurance Department

6.3 AHF : Animal House Facility

6.4 AR : Analytical Reagent

6.5 GR : Guaranteed Reagent

6.6 LR : Laboratory Reagent

6.7 ACS : American Chemical Society

7.0 REFERENCES

7.1 In-house

                                                         END OF THE DOCUMENT

You may like to read these links: 

1. List of All SOPs and Documents for the Chemistry Laboratory

2. List of All SOPs and Documents for Quality Control

3. List of All SOPs and Documents For Quality Assurance Dept.

4. List of SOPs and Documents Required to Achieve NABL Accreditation 

5. List of All SOPs and Documents for Laboratory Instruments and Equipment  

6. List of SOPs and Documents for Laboratory Administration

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