SOP FOR HANDLING OF ANIMAL MORBIDITY AND MORTALITY IN ANIMAL HOUSE FACILITY | STANDARD OPERATING PROCEDURE FOR HANDLING OF ANIMAL MORBIDITY AND MORTALITY IN ANIMAL HOUSE FACILITY

                   1.0                            OBJECTIVE

1.1                            To lay down a standard procedure to be followed for the handling of animal morbidity and mortality in Animal House Facility.

2.0                            SCOPE

2.1                            This Standard Operating Procedure (SOP) shall be applicable for the handling of animal morbidity and mortality in Animal House Facility.

3.0                            RESPONSIBILITY

3.1                            Head- Animal House Facility / Study Director

3.2                            Attendant- Animal House Facility

4.0                            DEFINITIONS

4.1                            Nil

5.0                            PROCEDURE

5.1                            Handling the Animals Found Moribund for Moribund Sacrifice

1.0                       

2.0                       

3.0                       

4.0                       

5.0                       

6.0                       

7.0                       

8.0                       

8.1                       

5.1.1                      If the animal is found moribund, separate the animal from the cage.

5.1.2                      Collect the blood sample if required, or as per the study plan (SP).

5.1.3                      The animal is then euthanized and the necropsy procedures, as mentioned in the currently running version of SOP............... and/or as mentioned in the SP are carried out.

5.1.4                      Organs/tissues shall be collected as per the currently running version of SOP..... and/or as mentioned in the SP.

5.1.5                      The experimental animals that are sacrificed based on their Moribundity will be considered equivalent to animals that died during the study.

5.2                            Handling the animal(s) found dead

8.1 

5.2.1                      If an animal is found dead during the study, then remove the dead animal from the cage.

5.2.2                      Identify the animal and mark it as “found dead” on the respective animal cage card.

5.2.3                      Assess the condition of the carcass and cut open the animal for the gross examination of vital organs as per the currently running version of SOP…….. and record the observations if any.

5.2.4                      Organs/tissues shall be collected as per the study plan and current running version of SOP No. ….

5.2.5                      If the reason for death is found due to overdosing / disease-related to experimental work, then the decision for other experimental animals shall be made by the study director and QA.

5.2.6                      If a non-experimental animal dies due to some disease, then assess the health status of the remaining animals and give proper treatment if required.

5.2.7                      Necropsy should be conducted by a trained person.

5.2.8                      If a trained person is not available (like on holidays) then label the animal with the following identification; Study No, the group no. animal no, sex, date, and approximate time when found dead and place the carcass in a plastic bag and store in refrigerator at 2-8ºC until further postmortem examination and organ collection (if defined in SP).

5.2.9 The record of animals that died during experiments shall be documented as raw data in the current running version of format no. F………...

5.2.10                  Record of non-experimental mortality shall be documented in current running version format no. F…………….

6.0                            ENCLOSURES

6.1                            Formats

Sr. No.	Format Title	Format No.	No. of pages
1	Experimental Raw Data Sheet For Mortality	F…………………….	01
2	Animal Mortality Record	F……………………..	01

7.0                            ABBREVIATIONS

7.1                            SOP                     : Standard Operating Procedure

7.2                            QAD                    : Quality Assurance Department

7.3                            AHF                     : Animal House Facility

8.0                            REFERENCES

8.1                            In-house

9.0                            REVISION HISTORY

Sr. No.	Change Control No.	Reason for change

                                                                                                                 

END OF DOCUMENT

You may like to read these links: 

1. Check Out the Tricks and Tips with Some Trouble Points While Conducting in OECD 407 and 408

2. List of OECD Guidelines or Toxicological Studies

3. List of Guidelines Used for Medical Devices Testing 

4. What are Bradford Hill's criteria for any chemical identification?

5. Animal  Facility Design - Small Laboratory Animals (Rat, Mice, Rabbit, Guinea Pig)

6. List of Chemicals Needed for In-vivo Laboratory

7. OECD Test Guidelines 425 detailedOutlines| AOT425StatPgm Software Installation LD50 Calculation

8. List of Guidelines for Toxicology Animal Studies 

9. List of All SOPs and Documents for the Animal House Facility

10. List of All SOPs and Documents for In-vivo Laboratory

Enable GingerCannot connect to Ginger Check your internet connection
or reload the browserDisable in this text fieldEditEdit in GingerEdit in Ginger×

Enable GingerCannot connect to Ginger Check your internet connection
or reload the browserDisable in this text fieldRephraseRephrase current sentenceEdit in Ginger×

SHARE

Owner

Hi. I’m Writer of Researchsop.com. ’ ’ Please share these SOPs to all concern pharma people for their development. I like to fullfill the need of curious people. These things inspire me to make things looks better.

• 
• 
• 
• 
•