2.0 RESPONSIBILITY: It is the responsibility of Animals Care Personals, Veterinary Personal and Principal Investigator.
3.0 PROCEDURE:
3.1 The species, strain, age, date of birth, sex, the number of animals, source and health status report (provided by vendor) of the animals should be checked.
3.2 Veterinary examination should be performed as early as possible post receiving of animal in the Quarantine Room.
3.3 Determine whether or not tests are necessary. This is determined according to the requirements of the destination facility.
3.4 Quarantine period should be minimum 7 days.
3.5 Observation and Special Care:
3.5.1 At a maximum of 72 hours after arrival, a subset of the shipment will be evaluated for parasitic infestation (ecto/endo).
3.5.2 The animals should be checked at least once daily.
3.5.3 The animals with clinical signs should be reported, to the veterinary care staff.
3.5.4 If deaths occur, the carcasses are stored in the designated refrigerator and the veterinary care staff along with the import coordinator should be informed.
3.5.5 For unexplained morbidity/mortality, the blood is collected when possible (for serology), gross necropsy is performed and tissues are collected for histopathology.
3.5.6 If required and suggested by veterinarian, animal should be treated with anthelmintics.
3.5.7 The total time from receipt of the rodents by ..... to release into the animal colony is typically one week.
The investigator should receive verification of the health status of the animals upon completion of the quarantine period.
3.6 If required following testing should be done:
3.6.1 Parasitological: Fresh feces from each imported mouse are pooled per strain for flotation. Acetate tape tests are taken from 2 imported animals per cage.
3.6.2 Pasteurella: Oral swabs are taken from 4 to 8 imported animals per strain. Oral swabs can also be pooled from each cage.
3.6.3 Special serological test should be performed if necessary.
4.0 PRECAUTIONS:
4.1 Details of the animals provided by the vendor should be checked thoroughly.
4.2 If required, microbial tests should be performed carefully.
5.0 REFERENCES:
5.1 Artwohl J, Brown P, Corning B, Stein S. ACLAM Task Force. Report of the ACLAM Task Force on Rodent Euthanasia. JAALAS. 2006;45:98–105. [PubMed]
5.2 ASR [Academy of Surgical Research] Guidelines for training in surgical research with animals. J Invest Surg.2009;22:218–225. [PubMed]
5.3 AVMA [American Veterinary Medical Association] A Report from the American Veterinary Medical Association Animal Air Transportation Study Group. Schaumburg, IL: AVMA; 2002.
5.4 AVMA. AVMA Guidelines on Euthanasia. Schaumburg, IL: AVMA; 2007.
5.5 Ayliffe GAJ. Role of the environment of the operating suite in surgical wound infection. Rev Infect Dis.1991;13(Suppl 10):S800–S804. [PubMed]
END OF THE DOCUMENT
You may like to read these links:
1. List of In-vivo laboratory Vendors (Capex)
2. List of SOPs and Documents for CPCSEA
3. List of All SOPs and Documents for Laboratory Instruments and Equipment
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