2.0 RESPONSIBILITY: It is the responsibility of the Animal House in charge and Animal Care Personnel to ensure that whoever enters the Animal House Facility follows the correct path.
3.0 PROCEDURE (for visitor and staff movement):
3.1 Entry procedure-
3.1.1 The respective section should be entered through the respective main door.
3.1.2 Personal belongings should be kept in the cupboard provided in the changing room.
3.1.3 The worn clothes should be kept inside the cupboard and the uniform along with the personnel protective equipment (PPE) such as face mask, caps, and hand gloves should be worn. Hands should be washed with an alcohol-based disinfectant solution.
3.1.4 After crossing the cross-over bench, slippers/shoe covers should be worn.
3.1.5 An entry register should be made available in the changing room and a person should make entry before entering the facility.
3.2 Exit Procedure-
3.2.1 The nose mask and hand gloves should be removed and kept inside the dustbin.
3.2.2 The animal house apron/coat should be removed and hung onto the hanger provided.
3.2.3 The footwear should be removed and left in the cupboard.
4.0 PROCEDURE (for live/dead animals):
4.1 Live animal movement:
4.1.1 Laboratory animals are very sensitive to their living conditions. It is important that they be housed in an isolated building located as far away as possible from human habitations and should not be exposed to dust, smoke, noise, wild rodents, insects, and birds. The building, cages, and environment of animal rooms are the major factors, which affect the quality of animals.
4.1.2 On arrival, labels on shipping cartoons should be checked to ensure that the animals are delivered to the correct location.
4.1.3 Information on transporting vehicle cartoons should be compared to purchase requisition to establish that the following is correct:
4.1.3.1 Numbers of animals
4.1.3.2 Purchase order number
4.1.3.3 Species
4.1.3.4 Strain
4.1.3.5 Sex
4.1.3.6 Ordered size
4.1.4 Animals should be inspected by the veterinarian or his/her designee for general health, which was documented. Sick animals should be isolated, rejected, or sacrificed.
4.1.5 Ear tags on incoming transporting vehicle cartoons should be verified that they match the ear tag numbers included on the transporting vehicle invoice.
4.1.6 Rats and/or mice should be taken to the appropriate floor, animal caretaker or floor supervisor should be notified.
4.1.7 Cages, runs and pens should be kept in good condition to prevent injuries to animals, promote physical comfort, and facilitate sanitation and servicing. Particular attention should be given to eliminating sharp edges and broken wires, and keeping cage floors in good condition.
4.1.8 When animals are maintained in outdoor runs, pens, or other large enclosures, there should be protection from extremes in temperature or other harsh weather conditions and adequate protective and escape mechanisms for submissive animals.
4.2 Dead animal movement:
4.2.1 A contact sheet was placed in each room that identifies an individual(s) of the research staff to be contacted in the event of an emergency, their phone, and specific instructions for animals found moribund or dead.
4.2.2 If a moribund animal is observed, animal care staff review the Contact Sheet for any specific instruction from the research staff, and in addition to these instructions, report the animal’s condition.
4.2.3 If any time there is a medical emergency, the attending clinical veterinarian or designee is to be notified immediately.
4.2.4 Staff should immediately report all medical emergencies verbally directly to the facility manager or if a facility manager is not available, the clinical veterinarian.
4.2.5 When an animal is found moribund, the facility manager must notify the attending research staff immediately of the animal’s condition, and request that the research staff assess the animal’s condition immediately to resolve the problem, and if necessary contact the clinical veterinarian to ensure prompt resolution of the animal’s condition.
4.3 When an animal is found dead:
4.3.1 Record found dead on the animal cage card.
4.3.2 Review the contact sheet for any specific instructions from the research staff regarding animals e.g. request notification, specific procedure for handling carcasses, and/or GLP requirements.
4.3.3 If there is no specific instructions, place the carcass in a plastic, and place the bag in the freezer designated for animal carcasses.
4.3.4 Daily record the number of animals found dead.
4.3.5 The appropriate personnel are notified promptly when an unanticipated animal death occurs, which necessitates immediate necropsy.
4.3.6 If the last animal in the cage is found dead, remove the cage to dirty cage wash, and if requested, provide the cage card to the research staff.
4.3.7 Deduct the number of animals (s) from the animal record sheet when applicable.
4.3.8 Eatables are strictly prohibited in the unit, entry to the toilet without proper uniform and footwear is strictly prohibited. Wristwatches and fingerrings are restricted inside hygienic areas. No person shall come out of the change room with animal house aprons.
5.0 PRECAUTIONS:
5.1 The movement of personnel in and around the animal house facility should be monitored strictly.
5.2 No eatables should be allowed in the animal house facility.
5.3 The animal care staff should be trained thoroughly on how to move around the facility, on how to bring that feed in, and on how to take the dead/ necropsied animals out.
5.4 The animals should not be given anything to eat else than the prescribed feed.
5.5 The concept behind the clean and dirty corridor should be explained to the animal care personnel.
6.0 REFERENCES:
6.1 Huerkamp MJR. Alcohol as a disinfectant for aseptic surgery of rodents: Crossing the thin blue line? Contemp Top Lab Anim Sci. 2002; 41:10–12. [PubMed]
6.2 Hughes HC, Lang CM. Control of pain in dogs and cats. Animal Pain: Perception and Alleviation. Kitchell RL, Erickson HH, editors. Bethesda, MD: American Physiological Society; 1983. pp. 207–216.
6.3 Hunt RD, Melendez LV. Spontaneous herpes-T infection in the owl monkey (Aotus trivirgatus) Pathol Vet.1966; 3:1–26. [PubMed]
6.4 IATA [International Air Transport Association] Live Animal Regulations (LAR) 36th ed. 2009. [accessed May 15, 2010]. Available at www.iata.org/ps/publications/Pages/live-animals.aspx.
6.5 IRAC [Interagency Research Animal Committee] U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Federal Register, May 20. Washington: Office of Science and Technology Policy; 1985. [PubMed]
******************************************************************************
3.1.1 The respective section should be entered through the respective main door.
3.1.2 Personal belongings should be kept in the cupboard provided in the changing room.
3.1.3 The worn clothes should be kept inside the cupboard and the uniform along with the personnel protective equipment (PPE) such as face mask, caps, and hand gloves should be worn. Hands should be washed with an alcohol-based disinfectant solution.
3.1.4 After crossing the cross-over bench, slippers/shoe covers should be worn.
3.1.5 An entry register should be made available in the changing room and a person should make entry before entering the facility.
3.2 Exit Procedure-
3.2.1 The nose mask and hand gloves should be removed and kept inside the dustbin.
3.2.2 The animal house apron/coat should be removed and hung onto the hanger provided.
3.2.3 The footwear should be removed and left in the cupboard.
4.0 PROCEDURE (for live/dead animals):
4.1 Live animal movement:
4.1.1 Laboratory animals are very sensitive to their living conditions. It is important that they be housed in an isolated building located as far away as possible from human habitations and should not be exposed to dust, smoke, noise, wild rodents, insects, and birds. The building, cages, and environment of animal rooms are the major factors, which affect the quality of animals.
4.1.2 On arrival, labels on shipping cartoons should be checked to ensure that the animals are delivered to the correct location.
4.1.3 Information on transporting vehicle cartoons should be compared to purchase requisition to establish that the following is correct:
4.1.3.1 Numbers of animals
4.1.3.2 Purchase order number
4.1.3.3 Species
4.1.3.4 Strain
4.1.3.5 Sex
4.1.3.6 Ordered size
4.1.4 Animals should be inspected by the veterinarian or his/her designee for general health, which was documented. Sick animals should be isolated, rejected, or sacrificed.
4.1.5 Ear tags on incoming transporting vehicle cartoons should be verified that they match the ear tag numbers included on the transporting vehicle invoice.
4.1.6 Rats and/or mice should be taken to the appropriate floor, animal caretaker or floor supervisor should be notified.
4.1.7 Cages, runs and pens should be kept in good condition to prevent injuries to animals, promote physical comfort, and facilitate sanitation and servicing. Particular attention should be given to eliminating sharp edges and broken wires, and keeping cage floors in good condition.
4.1.8 When animals are maintained in outdoor runs, pens, or other large enclosures, there should be protection from extremes in temperature or other harsh weather conditions and adequate protective and escape mechanisms for submissive animals.
4.2 Dead animal movement:
4.2.1 A contact sheet was placed in each room that identifies an individual(s) of the research staff to be contacted in the event of an emergency, their phone, and specific instructions for animals found moribund or dead.
4.2.2 If a moribund animal is observed, animal care staff review the Contact Sheet for any specific instruction from the research staff, and in addition to these instructions, report the animal’s condition.
4.2.3 If any time there is a medical emergency, the attending clinical veterinarian or designee is to be notified immediately.
4.2.4 Staff should immediately report all medical emergencies verbally directly to the facility manager or if a facility manager is not available, the clinical veterinarian.
4.2.5 When an animal is found moribund, the facility manager must notify the attending research staff immediately of the animal’s condition, and request that the research staff assess the animal’s condition immediately to resolve the problem, and if necessary contact the clinical veterinarian to ensure prompt resolution of the animal’s condition.
4.3 When an animal is found dead:
4.3.1 Record found dead on the animal cage card.
4.3.2 Review the contact sheet for any specific instructions from the research staff regarding animals e.g. request notification, specific procedure for handling carcasses, and/or GLP requirements.
4.3.3 If there is no specific instructions, place the carcass in a plastic, and place the bag in the freezer designated for animal carcasses.
4.3.4 Daily record the number of animals found dead.
4.3.5 The appropriate personnel are notified promptly when an unanticipated animal death occurs, which necessitates immediate necropsy.
4.3.6 If the last animal in the cage is found dead, remove the cage to dirty cage wash, and if requested, provide the cage card to the research staff.
4.3.7 Deduct the number of animals (s) from the animal record sheet when applicable.
4.3.8 Eatables are strictly prohibited in the unit, entry to the toilet without proper uniform and footwear is strictly prohibited. Wristwatches and fingerrings are restricted inside hygienic areas. No person shall come out of the change room with animal house aprons.
5.0 PRECAUTIONS:
5.1 The movement of personnel in and around the animal house facility should be monitored strictly.
5.2 No eatables should be allowed in the animal house facility.
5.3 The animal care staff should be trained thoroughly on how to move around the facility, on how to bring that feed in, and on how to take the dead/ necropsied animals out.
5.4 The animals should not be given anything to eat else than the prescribed feed.
5.5 The concept behind the clean and dirty corridor should be explained to the animal care personnel.
6.0 REFERENCES:
6.1 Huerkamp MJR. Alcohol as a disinfectant for aseptic surgery of rodents: Crossing the thin blue line? Contemp Top Lab Anim Sci. 2002; 41:10–12. [PubMed]
6.2 Hughes HC, Lang CM. Control of pain in dogs and cats. Animal Pain: Perception and Alleviation. Kitchell RL, Erickson HH, editors. Bethesda, MD: American Physiological Society; 1983. pp. 207–216.
6.3 Hunt RD, Melendez LV. Spontaneous herpes-T infection in the owl monkey (Aotus trivirgatus) Pathol Vet.1966; 3:1–26. [PubMed]
6.4 IATA [International Air Transport Association] Live Animal Regulations (LAR) 36th ed. 2009. [accessed May 15, 2010]. Available at www.iata.org/ps/publications/Pages/live-animals.aspx.
6.5 IRAC [Interagency Research Animal Committee] U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Federal Register, May 20. Washington: Office of Science and Technology Policy; 1985. [PubMed]
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END OF THE DOCUMENT
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