Calculating Creatinine Clearance, BUN Clearance, and Glomerular Filtration Rate (GFR) requires specific formulas and measurements. These calculations are commonly used to assess kidney function.
Creatinine Clearance (CrCl):
Creatinine clearance is a measure of how well the kidneys
are filtering creatinine from the blood. It is commonly used to estimate the
glomerular filtration rate (GFR), which indicates kidney function.
Formula:
CrCl (ml/min) = (Urine creatinine concentration (mg/dL) x Urine volume (ml/min)) / Plasma creatinine concentration (mg/dL)
Note: In the formula, urine creatinine concentration and urine volume are typically measured from a 24-hour urine collection and plasma creatinine concentration is obtained from a blood test.
Creatinine Clearance = (1000 X Urine Volume X Concentration of Creatinine in Urine)/Concentration of Creatinine in Plasma
BUN Clearance (Blood Urea Nitrogen Clearance):
BUN clearance assesses how well the kidneys are clearing
urea (a waste product) from the blood.
Formula:
BUN Clearance (ml/min) = (Urine urea concentration (mg/dL) x Urine volume (ml/min)) / Plasma urea concentration (mg/dL)
As with creatinine clearance, urine urea concentration, and urine volume are generally measured from a 24-hour urine collection, and plasma urea concentration is obtained from a blood test.
Glomerular Filtration Rate (GFR):
GFR is a measure of how effectively the kidneys are
filtering waste products and excess fluids from the blood. It is considered the
best indicator of kidney function.
There are several equations used to estimate GFR, and the most commonly used one is the Modification of Diet in Renal Disease (MDRD) equation:
GFR (ml/min/1.73m^2) = 175 x (Serum creatinine)^(-1.154) x (Age)^(-0.203) x (0.742 if female) x (1.212 if African American)
GFR is the mean of Creatinine clearance and BUN clearance
The measurements for urine volume are expressed in milliliters (mL), and the urinary concentrations of creatinine and Urine Urea Nitrogen (UUN) are in millimoles per liter (mmol/L). On the other hand, the serum concentration of creatinine is in micromoles per liter (µmol/L), and the serum concentrations of BUN are in millimoles per liter (mmol/L).
Please note that these formulas provide estimates of kidney
function and are not as accurate as direct measurements using
radioisotope-based methods. Always consult a healthcare professional for
accurate assessment and interpretation of kidney function.
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