The mechanism of action for folic acid-induced acute renal failure:
Folic acid is a water-soluble vitamin that is essential for DNA synthesis and cell growth.
In high doses, folic acid can cause oxidative stress and mitochondrial damage.
Oxidative stress is a condition in which there is an imbalance between the production of free radicals and the body's ability to detoxify them.
Mitochondrial damage is damage to the mitochondria, which are the power plants of the cell.
When oxidative stress and mitochondrial damage occur in the kidneys, it can lead to acute renal failure.
Acute renal failure is a sudden loss of kidney function.
It can be caused by a variety of factors, including infections, medications, and toxins.
The exact mechanism by which folic acid causes acute renal failure is not fully understood. However, it is thought that oxidative stress and mitochondrial damage caused by folic acid may lead to the death of kidney cells.
This can lead to a decrease in the glomerular filtration rate, which is the rate at which the kidneys filter blood.
A decrease in the glomerular filtration rate can lead to the accumulation of toxins and waste products in the blood, which can damage other organs and systems in the body.
Acute renal failure is a serious condition that can be fatal. If you experience symptoms of acute renal failure, such as decreased urine output, swelling, and fatigue, it is important to seek medical attention immediately.
Here are some additional information about folic acid-induced acute renal failure:
- The risk of acute renal failure from folic acid is increased in people with underlying kidney disease.
- The risk of acute renal failure from folic acid is also increased in people who take high doses of folic acid.
- Acute renal failure from folic acid usually resolves within a few weeks after stopping folic acid.
- In some cases, treatment with dialysis may be necessary.
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